One particular advantage of using zebrafish to study cancer biology is the ability to transplant human tumors into fish using established methods. Authors Leonard Zon, Ph.D., and Alison Taylor, Ph.D., present from Boston’s Harvard Medical School and Children’s Hospital concepts and techniques relevant to the analysis of the transplantation of zebrafish. They describe how tumor transplantation has been used to study leukemia, rhabdomyosarcoma, and melanoma in “The Role of Zebrafish Tumor Analysis: The State of Transplantation.”
The molecular basis for cancers that affect human germ cells is poorly understood, preventing efforts to determine more effective and targeted treatments. In the paper entitled “Identification of a Hereditary Model of the Testicular Tumor of the Germ Cell in the Zebrafish,” Joanie Neumann authors, Jennifer Dhepard Dovey, Garvin’s Cerero, Liliana Carbajal, and James Amatruda, describe the development of a model of the zebrafish that carries a genetic mutation that makes the fish highly susceptible to the development of testicular tumors. This model system can be used to test new approaches to therapy for testicular cancer.
June Chen and Jinrong Peng, from the University of Zhejian (China), describe the use of transgenic zebrafish to understand the roles that various natural forms of the p53 tumor suppressor gene play in cell cycle, metabolism, organ development, and aging and death of cell regulation. Its role “p53 Isoform Δ113p53 in Zebrafish” discusses the potential use of this isoform determined p53 to characterize factors in the p53 pathway and to revise them for novel cancer therapies.
Observing the “relative ease and low costs of transgenesis” – putting human genes on zebrafish – and the unique advantages of working with zebrafish, especially related to imaging, genetics, and transplantation, Dr. Leach predicts that, “Cancer research Futura of the zebrafish that exploits these fundamental advantages will be especially likely to generate new insights not achievable using other model systems,” in his Introduction to the Titled Edition, “Pisces and Cancer: The Stars Line.” Zebrafish services